TLR1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2Z7X, 1FYV

Identifiers

TLR1, CD281, TIL, TIL. LPRS5, rsc786, toll like receptor 1

External IDs

Gene ontology
Molecular function	• Toll-like receptor 2 binding • protein binding • protein heterodimerization activity • receptor activity • lipopeptide binding • transmembrane signaling receptor activity
Cellular component	• integral component of membrane • phagocytic vesicle membrane • Golgi apparatus • membrane • plasma membrane • Toll-like receptor 1-Toll-like receptor 2 protein complex • integral component of plasma membrane • membrane raft • cytoplasmic vesicle
Biological process	• defense response • toll-like receptor TLR1:TLR2 signaling pathway • positive regulation of tumor necrosis factor biosynthetic process • immune system process • regulation of cytokine secretion • MyD88-dependent toll-like receptor signaling pathway • positive regulation of interleukin-6 biosynthetic process • cellular response to triacyl bacterial lipopeptide • detection of triacyl bacterial lipopeptide • immune response • toll-like receptor 1 signaling pathway • macrophage activation • inflammatory response • signal transduction • innate immune response • defense response to bacterium • toll-like receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7096


21897


ENSG00000174125


ENSMUSG00000044827


Q15399


Q9EPQ1

RefSeq (mRNA)


NM_003263


NM_001276445 NM_030682

RefSeq (protein)


NP_003254


NP_001263374.1 NP_109607.1 NP_001263374 NP_109607

Location (UCSC)

PubMed search

TLR 1 is a member of the toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281 (cluster of differentiation 281).