TLR-2

TLR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Identifiers
Aliases	TLR2, CD282, TIL4, toll like receptor 2
External IDs	OMIM: 603028 MGI: 1346060 HomoloGene: 20695 GeneCards: TLR2
Gene location (Human) Chr. Chromosome 4 (human) Band 4q31.3 Start 153,701,500 bp End 153,705,699 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band n/a Start 83,836,272 bp End 83,841,767 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • signaling pattern recognition receptor activity • lipopolysaccharide binding • Toll-like receptor binding • triacyl lipopeptide binding • protein binding • peptidoglycan binding • protein heterodimerization activity • lipopolysaccharide receptor activity • transmembrane signaling receptor activity • receptor activity • lipopeptide binding Cellular component • cytoplasm • integral component of membrane • phagocytic vesicle membrane • Golgi apparatus • membrane • intrinsic component of plasma membrane • plasma • Toll-like receptor 1-Toll-like receptor 2 protein complex • integral component of plasma membrane • membrane raft • cytoplasmic vesicle • cell projection • cell surface • cell body Biological process • interleukin-10 production • positive regulation of interferon-beta production • defense response to Gram-positive bacterium • positive regulation of interleukin-18 production • positive regulation of toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • positive regulation of inflammatory response • cellular response to bacterial lipopeptide • positive regulation of interleukin-12 production • immune system process • detection of diacyl bacterial lipopeptide • regulation of cytokine secretion • cellular response to diacyl bacterial lipopeptide • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • MyD88-dependent toll-like receptor signaling pathway • cellular response to triacyl bacterial lipopeptide • detection of triacyl bacterial lipopeptide • positive regulation of Wnt signaling pathway • positive regulation of gene expression • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • immune response • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • cytokine secretion involved in immune response • positive regulation of chemokine production • positive regulation of NF-kappaB import into nucleus • innate immune response • inflammatory response • toll-like receptor TLR6:TLR2 signaling pathway • response to molecule of bacterial origin • signal transduction • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • response to lipopolysaccharide • response to progesterone • toll-like receptor signaling pathway • response to insulin • central nervous system myelin formation • nitric oxide metabolic process • response to fatty acid • leukotriene metabolic process • toll-like receptor 2 signaling pathway • positive regulation of oligodendrocyte differentiation • response to bacterial lipoprotein • negative regulation of cell proliferation • response to toxic substance • response to hypoxia • positive regulation of interleukin-10 production • lipopolysaccharide-mediated signaling pathway • microglial cell activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7097	24088
Ensembl	ENSG00000137462	ENSMUSG00000027995
UniProt	O60603	Q9QUN7
RefSeq (mRNA)	NM_003264 NM_001318787 NM_001318789 NM_001318790 NM_001318791 NM_001318793 NM_001318795 NM_001318796	NM_011905
RefSeq (protein)	NP_001305716 NP_001305718 NP_001305719 NP_001305720 NP_001305722 NP_001305724 NP_001305725 NP_003255	NP_036035
Location (UCSC)	Chr 4: 153.7 – 153.71 Mb	Chr 4: 83.84 – 83.84 Mb
PubMed search

1FYW, 1FYX, 1O77, 2Z7X, 2Z80

7097

24088

ENSG00000137462

ENSMUSG00000027995

O60603

Q9QUN7

NM_001318793
NM_001318795
NM_001318796

NM_011905

NP_001305724
NP_001305725
NP_003255

NP_036035

Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system.

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