TIMP4

TIMP4
Identifiers
Aliases	TIMP4, TIMP metallopeptidase inhibitor 4
External IDs	MGI: 109125 HomoloGene: 37748 GeneCards: TIMP4
Gene ontology Molecular function • peptidase inhibitor activity • enzyme inhibitor activity • metal ion binding • protease binding • metalloendopeptidase inhibitor activity Cellular component • proteinaceous extracellular matrix • sarcomere • extracellular region • extracellular space Biological process • Notch signaling pathway • negative regulation of peptidase activity • response to peptide hormone • central nervous system development • response to lipopolysaccharide • ovulation cycle • negative regulation of membrane protein ectodomain proteolysis • response to drug • negative regulation of catalytic activity • negative regulation of endopeptidase activity • response to hormone • response to cytokine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7079	110595
Ensembl	ENSG00000157150	ENSMUSG00000030317
UniProt	Q99727	Q9JHB3
RefSeq (mRNA)	NM_003256	NM_080639
RefSeq (protein)	NP_003247	NP_542370
Location (UCSC)	Chr 3: 12.15 – 12.16 Mb	Chr 6: 115.24 – 115.25 Mb
PubMed search

7079

110595

ENSG00000157150

ENSMUSG00000030317

Q99727

Q9JHB3

NM_003256

NM_080639

NP_003247

NP_542370

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.

TIMP4 has been shown to interact with MMP2.

...
Wikipedia