TIMP3

TIMP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CKI
Identifiers
Aliases	TIMP3, HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3
External IDs	MGI: 98754 HomoloGene: 36322 GeneCards: TIMP3
Gene ontology Molecular function • peptidase inhibitor activity • enzyme inhibitor activity • metal ion binding • protease binding • protein binding • metalloendopeptidase inhibitor activity Cellular component • extracellular matrix • proteinaceous extracellular matrix • basement membrane • extracellular exosome • nucleus • extracellular region • platelet dense granule lumen • extracellular space Biological process • cellular response to organic substance • negative regulation of peptidase activity • response to stimulus • positive regulation of TRAIL-activated apoptotic signaling pathway • negative regulation of ERK1 and ERK2 cascade • negative regulation of membrane protein ectodomain proteolysis • visual perception • platelet degranulation • response to organic substance • negative regulation of metalloendopeptidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7078	21859
Ensembl	ENSG00000100234	ENSMUSG00000020044
UniProt	P35625	P39876
RefSeq (mRNA)	NM_000362	NM_011595
RefSeq (protein)	NP_000353	NP_035725
Location (UCSC)	Chr 22: 32.8 – 32.86 Mb	Chr 10: 86.3 – 86.35 Mb
PubMed search

3CKI

7078

21859

ENSG00000100234

ENSMUSG00000020044

P35625

P39876

NM_000362

NM_011595

NP_000353

NP_035725

Metalloproteinase inhibitor 3 is an protein that in humans is encoded by the TIMP3 gene.

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.

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