TIMP2

TIMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BR9, 1GXD, 2TMP, 4ILW
Identifiers
Aliases	TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2
External IDs	MGI: 98753 HomoloGene: 2444 GeneCards: TIMP2
Gene location (Human) Chr. Chromosome 17 (human) Band No data available Start 78,852,977 bp End 78,925,387 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band No data available Start 118,301,069 bp End 118,355,740 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • enzyme inhibitor activity • metal ion binding • integrin binding • protein binding • protease binding • metalloendopeptidase inhibitor activity • zinc ion binding Cellular component • growth cone • proteinaceous extracellular matrix • extracellular region • cell surface • neuronal cell body • neuron projection • extracellular exosome • extracellular matrix • extracellular space • specific granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen Biological process • negative regulation of proteolysis • response to cytokine • negative regulation of peptidase activity • positive regulation of adenylate cyclase activity • aging • extracellular matrix disassembly • negative regulation of Ras protein signal transduction • central nervous system development • positive regulation of neuron differentiation • response to hormone • negative regulation of membrane protein ectodomain proteolysis • response to drug • positive regulation of MAPK cascade • negative regulation of cell proliferation • negative regulation of mitotic cell cycle • regulation of Rap protein signal transduction • negative regulation of endopeptidase activity • neutrophil degranulation • negative regulation of metallopeptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7077	21858
Ensembl	ENSG00000035862	ENSMUSG00000017466
UniProt	P16035	P25785
RefSeq (mRNA)	NM_003255	NM_011594
RefSeq (protein)	NP_003246	n/a
Location (UCSC)	Chr 17: 78.85 – 78.93 Mb	Chr 11: 118.3 – 118.36 Mb
PubMed search

1BR9, 1GXD, 2TMP, 4ILW

7077

21858

ENSG00000035862

ENSMUSG00000017466

P16035

P25785

NM_003255

NM_011594

NP_003246

n/a

Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor.

The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMP), a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. TIMP2 functions as both an MMP inhibitor and an activator. TIMPs inhibit active MMPs, but different TIMPs inhibit different MMPs better than others. For example, TIMP-1 inhibits MMP-7, MMP-9, MMP-1 and MMP-3 better than TIMP-2, and TIMP-2 inhibits MMP-2 more effectively than other TIMPs.

...
Wikipedia