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TGFBI

TGFBI
Protein TGFBI PDB 1x3b.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TGFBI, BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1, transforming growth factor beta induced
External IDs MGI: 99959 HomoloGene: 37294 GeneCards: TGFBI
RNA expression pattern
PBB GE TGFBI 201506 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000358

NM_009369

RefSeq (protein)

NP_000349

NP_033395.1
NP_033395

Location (UCSC) Chr 5: 136.03 – 136.06 Mb Chr 13: 56.61 – 56.64 Mb
PubMed search

1X3B, 2LTB, 2LTC, 2VXP

NM_000358

NM_009369

NP_000349

NP_033395.1
NP_033395

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion.


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Wikipedia

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