TGFB1

TGFB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Identifiers
Aliases	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta 1
External IDs	OMIM: 190180 MGI: 98725 HomoloGene: 540 GeneCards: TGFB1
Gene ontology Molecular function • type II transforming growth factor beta receptor binding • protein N-terminus binding • glycoprotein binding • cytokine activity • enzyme binding • growth factor activity • antigen binding • type I transforming growth factor beta receptor binding • protein homodimerization activity • protein serine/threonine kinase activator activity • protein binding • protein heterodimerization activity • type III transforming growth factor beta receptor binding • transforming growth factor beta receptor binding Cellular component • cytoplasm • extracellular region • nucleus • microvillus • cell surface • blood microparticle • proteinaceous extracellular matrix • plasma membrane • secretory granule • axon • neuronal cell body • Golgi lumen • platelet alpha granule lumen • extracellular matrix • extracellular space Biological process • positive regulation of histone deacetylation • positive regulation of transcription regulatory region DNA binding • ureteric bud development • tolerance induction to self antigen • positive regulation of protein phosphorylation • endoderm development • response to cholesterol • positive regulation of MAP kinase activity • regulation of sodium ion transport • response to progesterone • negative regulation of cell cycle • response to organic substance • mammary gland development • T cell homeostasis • negative regulation of ossification • negative regulation of hyaluronan biosynthetic process • protein phosphorylation • T cell differentiation • positive regulation of vascular permeability • animal organ regeneration • positive regulation of blood vessel endothelial cell migration • negative regulation of epithelial cell proliferation • regulation of binding • inner ear development • myelination • negative regulation of macrophage cytokine production • cell proliferation • transforming growth factor beta receptor signaling pathway • face morphogenesis • negative regulation of cell proliferation • positive regulation of receptor clustering • regulation of apoptotic process • defense response to fungus, incompatible interaction • positive regulation of collagen biosynthetic process • cellular response to transforming growth factor beta stimulus • pathway-restricted SMAD protein phosphorylation • regulation of DNA binding • regulation of actin cytoskeleton reorganization • negative regulation of fat cell differentiation • positive regulation of cellular protein metabolic process • cell-cell junction organization • negative regulation of myoblast differentiation • positive regulation of protein kinase B signaling • active induction of host immune response by virus • common-partner SMAD protein phosphorylation • positive regulation of branching involved in ureteric bud morphogenesis • SMAD protein signal transduction • epidermal growth factor receptor signaling pathway • macrophage derived foam cell differentiation • negative regulation of blood vessel endothelial cell migration • positive regulation of protein dephosphorylation • extrinsic apoptotic signaling pathway • SMAD protein import into nucleus • negative regulation of extracellular matrix disassembly • mitotic cell cycle checkpoint • positive regulation of fibroblast proliferation • negative regulation of cell differentiation • regulation of branching involved in mammary gland duct morphogenesis • positive regulation of exit from mitosis • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of gene expression • morphogenesis of a branching structure • regulation of SMAD protein import into nucleus • positive regulation of peptidyl-serine phosphorylation • cell activation • negative regulation of neuroblast proliferation • positive regulation of transcription, DNA-templated • cell growth • negative regulation of T cell proliferation • response to wounding • negative regulation of cell growth • positive regulation of chemotaxis • protein export from nucleus • regulation of protein import into nucleus • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein import into nucleus • positive regulation of cardiac muscle cell differentiation • oligodendrocyte development • positive regulation of interleukin-17 production • inflammatory response • negative regulation of interleukin-17 production • lymph node development • T cell activation • Notch signaling pathway • negative regulation of protein phosphorylation • regulation of blood vessel remodeling • SMAD protein complex assembly • regulation of striated muscle tissue development • response to vitamin D • chondrocyte differentiation • regulatory T cell differentiation • regulation of cartilage development • branch elongation involved in mammary gland duct branching • positive regulation of bone mineralization • positive regulation of epithelial cell proliferation • female pregnancy • cellular response to organic cyclic compound • positive regulation of extracellular matrix assembly • cellular calcium ion homeostasis • wound healing • negative regulation of transcription from RNA polymerase II promoter • response to glucose • positive regulation of epithelial to mesenchymal transition • cellular response to dexamethasone stimulus • negative regulation of production of miRNAs involved in gene silencing by miRNA • evasion or tolerance of host defenses by virus • lens fiber cell differentiation • positive regulation of NF-kappaB transcription factor activity • extracellular matrix assembly • ATP biosynthetic process • hematopoietic progenitor cell differentiation • regulation of interleukin-23 production • positive regulation of protein secretion • frontal suture morphogenesis • epithelial to mesenchymal transition • phosphate-containing compound metabolic process • regulation of gene expression • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • negative regulation of release of sequestered calcium ion into cytosol • response to radiation • mononuclear cell proliferation • negative regulation of transcription, DNA-templated • negative regulation of T cell activation • positive regulation of odontogenesis • lipopolysaccharide-mediated signaling pathway • positive regulation of protein localization to nucleus • response to estradiol • regulation of cell migration • response to hypoxia • hyaluronan catabolic process • negative regulation of phagocytosis • response to organic cyclic compound • positive regulation of protein complex assembly • protein kinase B signaling • negative regulation of cell-cell adhesion • negative regulation of gene silencing by miRNA • positive regulation of regulatory T cell differentiation • cellular response to growth factor stimulus • positive regulation of pathway-restricted SMAD protein phosphorylation • protein import into nucleus, translocation • mammary gland branching involved in thelarche • response to laminar fluid shear stress • aging • regulation of regulatory T cell differentiation • platelet degranulation • negative regulation of DNA replication • myeloid dendritic cell differentiation • salivary gland morphogenesis • receptor catabolic process • MAPK cascade • positive regulation of histone acetylation • regulation of transforming growth factor beta receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase activity • negative regulation of protein localization to plasma membrane • positive regulation of NAD+ ADP-ribosyltransferase activity • negative regulation of immune response • regulation of cell proliferation • negative regulation of skeletal muscle tissue development • positive regulation of peptidyl-threonine phosphorylation • positive regulation of smooth muscle cell differentiation • cell cycle arrest • positive regulation of isotype switching to IgA isotypes • connective tissue replacement involved in inflammatory response wound healing • ossification involved in bone remodeling • positive regulation of apoptotic process • positive regulation of vascular endothelial growth factor production • positive regulation of superoxide anion generation • digestive tract development • cell migration • positive regulation of fibroblast migration • positive regulation of cell division • response to drug • germ cell migration • positive regulation of transcription from RNA polymerase II promoter • negative regulation of mitotic cell cycle • positive regulation of SMAD protein import into nucleus • positive regulation of cell cycle arrest • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation of gene expression • positive regulation of cell proliferation • liver regeneration • regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of mononuclear cell migration • cellular response to insulin-like growth factor stimulus • positive regulation of cell migration • response to immobilization stress • cellular response to mechanical stimulus • cellular response to ionizing radiation • vasculogenesis • neural tube closure • heart valve morphogenesis • heart development • neural tube development • membrane protein intracellular domain proteolysis • leukocyte migration • ventricular cardiac muscle tissue morphogenesis • positive regulation of ERK1 and ERK2 cascade • transforming growth factor beta receptor signaling pathway involved in heart development • embryonic liver development • BMP signaling pathway • cell development • apoptotic process • regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation of production of miRNAs involved in gene silencing by miRNA Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7040	21803
Ensembl	ENSG00000105329	ENSMUSG00000002603
UniProt	P01137	P04202
RefSeq (mRNA)	NM_000660	NM_011577
RefSeq (protein)	NP_000651	NP_035707.1 NP_035707
Location (UCSC)	Chr 19: 41.3 – 41.35 Mb	Chr 7: 25.69 – 25.71 Mb
PubMed search

1KLA, 1KLC, 1KLD, 3KFD, 4KV5

7040

21803

ENSG00000105329

ENSMUSG00000002603

P01137

P04202

NM_000660

NM_011577

NP_000651

NP_035707.1
NP_035707

Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene.

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