TGFβR1

TGFBR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J, 4X2K, 4X2N, 4X2G, 4X2F, 5E8W, 5E8X, 5E8U, 5E8T, 5E8S, 5E90, 5E8Z
Identifiers
Aliases	TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, transforming growth factor beta receptor 1
External IDs	MGI: 98728 HomoloGene: 3177 GeneCards: TGFBR1
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.33 Start 99,104,038 bp End 99,154,192 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 B1|4 26.02 cM Start 47,353,222 bp End 47,414,931 bp
Gene ontology Molecular function • type II transforming growth factor beta receptor binding • signal transducer activity, downstream of receptor • I-SMAD binding • transforming growth factor beta-activated receptor activity • kinase activity • receptor binding • ATP binding • protein kinase activity • signal transducer, downstream of receptor, with serine/threonine kinase activity • metal ion binding • protein serine/threonine kinase activity • transforming growth factor beta receptor activity, type I • transferase activity • growth factor binding • transmembrane receptor protein serine/threonine kinase activity • protein binding • SMAD binding • nucleotide binding • transforming growth factor beta binding Cellular component • endosome • membrane • bicellular tight junction • cell surface • membrane raft • integral component of membrane • cell • receptor complex • plasma membrane • transforming growth factor beta receptor complex • cell junction • intracellular • intracellular membrane-bounded organelle Biological process • skeletal system development • response to cholesterol • regulation of protein ubiquitination • post-embryonic development • protein phosphorylation • negative regulation of chondrocyte differentiation • mesenchymal cell differentiation • angiogenesis • transforming growth factor beta receptor signaling pathway • positive regulation of filopodium assembly • extracellular structure organization • pharyngeal system development • apoptotic process • cellular response to transforming growth factor beta stimulus • pathway-restricted SMAD protein phosphorylation • positive regulation of protein kinase B signaling • regulation of transcription, DNA-templated • signal transduction by protein phosphorylation • activation of MAPKK activity • kidney development • collagen fibril organization • thymus development • cell motility • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of apoptotic signaling pathway • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of transcription, DNA-templated • heart development • positive regulation of cell growth • parathyroid gland development • artery morphogenesis • blastocyst development • activin receptor signaling pathway • palate development • cell differentiation • male gonad development • phosphorylation • skeletal system morphogenesis • wound healing • negative regulation of apoptotic process • epithelial to mesenchymal transition • regulation of gene expression • embryonic cranial skeleton morphogenesis • positive regulation of cellular component movement • peptidyl-threonine phosphorylation • intracellular signal transduction • positive regulation of endothelial cell proliferation • positive regulation of cell migration • regulation of epithelial to mesenchymal transition • positive regulation of pathway-restricted SMAD protein phosphorylation • endothelial cell activation • negative regulation of endothelial cell proliferation • transmembrane receptor protein serine/threonine kinase signaling pathway • lens development in camera-type eye • peptidyl-serine phosphorylation • cell cycle arrest • positive regulation of cell proliferation • regulation of growth • neuron fate commitment • regulation of protein binding • endothelial cell migration • germ cell migration • positive regulation of SMAD protein import into nucleus • cardiac epithelial to mesenchymal transition • signal transduction • anterior/posterior pattern specification • proepicardium development • ventricular trabecula myocardium morphogenesis • ventricular compact myocardium morphogenesis • positive regulation of epithelial to mesenchymal transition • protein deubiquitination • positive regulation of stress fiber assembly • regulation of cardiac muscle cell proliferation • ventricular septum morphogenesis • angiogenesis involved in coronary vascular morphogenesis • coronary artery morphogenesis • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of occluding junction disassembly • epicardium morphogenesis • positive regulation of apoptotic process • positive regulation of gene expression Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7046	21812
Ensembl	ENSG00000106799	ENSMUSG00000007613
UniProt	P36897	Q64729
RefSeq (mRNA)	NM_001130916 NM_001306210 NM_004612	NM_009370 NM_001312868 NM_001312869
RefSeq (protein)	NP_001124388 NP_001293139 NP_004603	NP_001299797 NP_001299798 NP_033396
Location (UCSC)	Chr 9: 99.1 – 99.15 Mb	Chr 9: 47.35 – 47.41 Mb
PubMed search

1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J, 4X2K, 4X2N, 4X2G, 4X2F, 5E8W, 5E8X, 5E8U, 5E8T, 5E8S, 5E90, 5E8Z

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