TFAP4

TFAP4
Identifiers
Aliases	TFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4)
External IDs	MGI: 103239 HomoloGene: 2424 GeneCards: TFAP4
Gene ontology Molecular function • sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein homodimerization activity • protein dimerization activity • transcription coactivator activity • histone deacetylase binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • DNA binding • E-box binding • transcription regulatory region DNA binding Cellular component • transcriptional repressor complex • nucleus • mitochondrion Biological process • negative regulation of cell proliferation • negative regulation of cyclin-dependent protein serine/threonine kinase activity • transcription, DNA-templated • negative regulation of gene expression • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • cellular response to dexamethasone stimulus • negative regulation of DNA binding • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • positive regulation of apoptotic process • positive regulation of transcription, DNA-templated • negative regulation by host of viral transcription • negative regulation of cell cycle arrest • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation by host of viral transcription • transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • protein complex assembly • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7023	83383
Ensembl	ENSG00000090447	ENSMUSG00000005718
UniProt	Q01664	n/a
RefSeq (mRNA)	NM_003223	NM_031182
RefSeq (protein)	NP_003214	n/a
Location (UCSC)	Chr 16: 4.26 – 4.27 Mb	Chr 16: 4.54 – 4.56 Mb
PubMed search

7023

83383

ENSG00000090447

ENSMUSG00000005718

Q01664

n/a

NM_003223

NM_031182

NP_003214

n/a

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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