TEP1

TEP1
Identifiers
Aliases	TEP1, TLP1, TP1, TROVE1, VAULT2, p240, telomerase associated protein 1
External IDs	MGI: 109573 HomoloGene: 5157 GeneCards: TEP1
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 20,365,667 bp End 20,413,429 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 C1|14 26.26 cM Start 50,824,062 bp End 50,870,560 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • ATP binding • p53 binding • nucleotide binding • enzyme binding • telomerase RNA binding • telomerase activity • RNA binding Cellular component • chromosome, telomeric region • telomerase holoenzyme complex • nucleus • cytoplasm • intracellular ribonucleoprotein complex • nuclear matrix • chromosome • U5 snRNP • precatalytic spliceosome • catalytic step 2 spliceosome Biological process • telomere maintenance via recombination • RNA-dependent DNA biosynthetic process • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7011	21745
Ensembl	ENSG00000129566	ENSMUSG00000006281
UniProt	Q99973	P97499
RefSeq (mRNA)	NM_007110 NM_001319035	NM_009351
RefSeq (protein)	NP_001305964 NP_009041	NP_033377
Location (UCSC)	Chr 14: 20.37 – 20.41 Mb	Chr 14: 50.82 – 50.87 Mb
PubMed search

7011

21745

ENSG00000129566

ENSMUSG00000006281

Q99973

P97499

NM_007110
NM_001319035

NM_009351

NP_001305964
NP_009041

NP_033377

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. It is also a minor vault protein.

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Wikipedia