TDP-43

TARDBP

Protein TARDBP PDB 1wf0.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WF0, 2CQG, 4BS2, 4IUF, 4Y0F, 2N4P, 2N2C, 4Y00, 2N4G, 2N4H, 2N3X

Identifiers

TARDBP, ALS10, TDP-43, TAR DNA binding protein

External IDs

MGI: 2387629 HomoloGene: 7221 GeneCards: TARDBP

Gene ontology
Molecular function	• nucleotide binding • DNA binding • transcription factor activity, sequence-specific DNA binding • mRNA 3'-UTR binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • identical protein binding • RNA binding • nucleic acid binding • double-stranded DNA binding
Cellular component	• cytoplasm • nuclear speck • nucleoplasm • interchromatin granule • perichromatin fibrils • nucleus
Biological process	• negative regulation of protein phosphorylation • regulation of transcription, DNA-templated • mRNA processing • negative regulation of gene expression • response to endoplasmic reticulum stress • transcription, DNA-templated • regulation of cell cycle • nuclear fragmentation involved in apoptotic nuclear change • negative regulation by host of viral transcription • RNA splicing • nuclear inner membrane organization • 3'-UTR-mediated mRNA stabilization • positive regulation of transcription from RNA polymerase II promoter • positive regulation of insulin secretion • transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE TARDBP 221264 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


23435


230908


ENSG00000120948


ENSMUSG00000041459


Q13148


Q921F2

RefSeq (mRNA)


NM_007375

NM_001003898 NM_001003899 NM_001008545 NM_001008546 NM_145556
NM_001305425

RefSeq (protein)


NP_031401 NP_031401.1

NP_001003899.1 NP_001008545.1 NP_001008546.1 NP_001292354.1 NP_663531.1
NP_001003898 NP_001003899 NP_001008545 NP_001008546 NP_001292354 NP_663531

Location (UCSC)

Chr 1: 11.01 – 11.03 Mb

Chr 4: 148.61 – 148.63 Mb

PubMed search

1WF0, 2CQG, 4BS2, 4IUF, 4Y0F, 2N4P, 2N2C, 4Y00, 2N4G, 2N4H, 2N3X

ENSG00000120948

ENSMUSG00000041459

NP_031401
NP_031401.1

NP_001003898
NP_001003899
NP_001008545
NP_001008546
NP_001292354
NP_663531

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Wikipedia

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