TCP1

TCP1
Identifiers
Aliases	TCP1, CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha, T-complex 1
External IDs	MGI: 98535 HomoloGene: 5656 GeneCards: TCP1
Gene ontology Molecular function • nucleotide binding • protein binding • ATP binding • ubiquitin protein ligase binding • protein binding involved in protein folding • unfolded protein binding • RNA binding Cellular component • cytoplasm • cell body • cytosol • centrosome • Golgi apparatus • pericentriolar material • myelin sheath • microtubule organizing center • nuclear heterochromatin • zona pellucida receptor complex • heterochromatin • acrosomal vesicle • chaperonin-containing T-complex • microtubule • extracellular exosome • cytoskeleton Biological process • tubulin complex assembly • positive regulation of protein localization to Cajal body • positive regulation of establishment of protein localization to telomere • scaRNA localization to Cajal body • regulation of macrophage apoptotic process • protein stabilization • positive regulation of telomere maintenance via telomerase • toxin transport • protein folding • positive regulation of telomerase activity • translocation of peptides or proteins into host cell cytoplasm • positive regulation of telomerase RNA localization to Cajal body • binding of sperm to zona pellucida • 'de novo' protein folding • chaperone-mediated protein folding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6950	21454
Ensembl	ENSG00000120438	ENSMUSG00000068039
UniProt	P17987	P11983
RefSeq (mRNA)	NM_030752 NM_001008897	NM_001290712 NM_013686
RefSeq (protein)	NP_001008897 NP_110379	NP_001277641.1 NP_038714.2 NP_001277641 NP_038714
Location (UCSC)	Chr 6: 159.78 – 159.79 Mb	Chr 17: 12.92 – 12.93 Mb
PubMed search

6950

21454

ENSG00000120438

ENSMUSG00000068039

P17987

P11983

NM_030752
NM_001008897

NM_001290712
NM_013686

NP_001008897
NP_110379

NP_001277641.1
NP_038714.2
NP_001277641
NP_038714

T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene.

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

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