TCF3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2MH0, 2YPA, 2YPB, 3U5V

Identifiers

Aliases

TCF3, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21, AGM8, transcription factor 3

External IDs

MGI: 98510 HomoloGene: 2408 GeneCards: TCF3

Genetically Related Diseases

Hodgkin's lymphoma

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • protein dimerization activity • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • mitogen-activated protein kinase kinase kinase binding • vitamin D response element binding • transcription coactivator activity • transcription factor binding • enhancer binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • bHLH transcription factor binding • E-box binding • protein binding • protein heterodimerization activity • transcription regulatory region DNA binding • repressing transcription factor binding
Cellular component	• cytoplasm • transcription factor complex • protein complex • RNA polymerase II transcription factor complex • nuclear chromatin • nucleus • nucleoplasm • nuclear speck
Biological process	• cell differentiation • regulation of transcription, DNA-templated • positive regulation of muscle cell differentiation • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • nervous system development • positive regulation of transcription, DNA-templated • regulation of G1/S transition of mitotic cell cycle • B cell lineage commitment • positive regulation of cell cycle • positive regulation of B cell proliferation • positive regulation of neuron differentiation • B cell differentiation • immunoglobulin V(D)J recombination • positive regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6929


21423

Ensembl


ENSG00000071564


ENSMUSG00000020167

UniProt


P15923


P15806

RefSeq (mRNA)


NM_001136139 NM_003200

NM_001164147 NM_001164148 NM_001164149 NM_001164150 NM_001164151
NM_001164152 NM_001164153 NM_011548

RefSeq (protein)


NP_001129611 NP_003191

NP_001157620.1 NP_001157621.1 NP_001157623.1 NP_035678.3 NP_001157619
NP_001157620 NP_001157621 NP_001157622 NP_001157623 NP_001157624 NP_001157625 NP_035678

Location (UCSC)

Chr 19: 1.61 – 1.65 Mb

Chr 10: 80.41 – 80.43 Mb

PubMed search

2MH0, 2YPA, 2YPB, 3U5V

NM_001136139
NM_003200

NM_001164152
NM_001164153
NM_011548

NP_001129611
NP_003191

NP_001157620
NP_001157621
NP_001157622
NP_001157623
NP_001157624
NP_001157625
NP_035678

...
Wikipedia