TAS2R10

TAS2R10
Identifiers
Aliases	TAS2R10, T2R10, TRB2, taste 2 receptor member 10
External IDs	MGI: 2681218 HomoloGene: 128355 GeneCards: TAS2R10
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.2 Start 10,825,317 bp End 10,826,358 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F3 Start 131,689,134 bp End 131,690,063 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • taste receptor activity • bitter taste receptor activity Cellular component • plasma membrane • membrane • integral component of membrane Biological process • detection of chemical stimulus involved in sensory perception of bitter taste • signal transduction • response to stimulus • sensory perception of taste • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50839	387346
Ensembl	ENSG00000272805 ENSG00000121318 ENSG00000277238	ENSMUSG00000063478
UniProt	Q9NYW0	Q7M722
RefSeq (mRNA)	NM_023921	NM_207019
RefSeq (protein)	NP_076410	NP_996902
Location (UCSC)	Chr 12: 10.83 – 10.83 Mb	Chr 12: 131.69 – 131.69 Mb
PubMed search

50839

387346

ENSG00000272805
ENSG00000121318
ENSG00000277238

ENSMUSG00000063478

Q9NYW0

Q7M722

NM_023921

NM_207019

NP_076410

NP_996902

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.

TAS2R10 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.

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Wikipedia