TAL1

TAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1
External IDs	OMIM: 187040 MGI: 98480 HomoloGene: 2400 GeneCards: TAL1
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein dimerization activity • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • histone deacetylase binding • chromatin binding • transcription regulatory region sequence-specific DNA binding • E-box binding • protein binding • protein heterodimerization activity • enzyme binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • histone deacetylase complex • transcription factor complex • protein complex • nuclear chromatin • Lsd1/2 complex • nucleus Biological process • megakaryocyte development • megakaryocyte differentiation • myeloid cell differentiation • hemopoiesis • cell fate commitment • cell differentiation • regulation of transcription, DNA-templated • regulation of mast cell differentiation • spinal cord association neuron differentiation • positive regulation of protein complex assembly • locomotory behavior • positive regulation of erythrocyte differentiation • regulation of transcription from RNA polymerase II promoter • regulation of stem cell population maintenance • platelet formation • positive regulation of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • generation of neurons • basophil differentiation • positive regulation of transcription, DNA-templated • multicellular organism development • regulation of cell proliferation • hematopoietic stem cell differentiation • astrocyte fate commitment • angiogenesis • neuron differentiation • embryonic hemopoiesis • positive regulation of chromatin assembly or disassembly • erythrocyte differentiation • definitive hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell division • hemangioblast cell differentiation • positive regulation of transcription from RNA polymerase II promoter • erythrocyte maturation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6886	21349
Ensembl	ENSG00000162367	ENSMUSG00000028717
UniProt	P17542	P22091
RefSeq (mRNA)	NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406 NM_003189	NM_011527 NM_001287388
RefSeq (protein)	NP_001274276 NP_001277332 NP_001277333 NP_001277334 NP_001277335 NP_003180	NP_001274317.1 NP_035657.1 NP_001274317 NP_035657
Location (UCSC)	Chr 1: 47.22 – 47.23 Mb	Chr 4: 115.06 – 115.07 Mb
PubMed search

2YPA, 2YPB

6886

21349

ENSG00000162367

ENSMUSG00000028717

P17542

P22091

NM_003189

NM_011527
NM_001287388

NP_003180

NP_001274317.1
NP_035657.1
NP_001274317
NP_035657

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

TAL1 has been shown to interact with:

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Wikipedia