TAFI

CPB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D66, 3D67, 3D68, 3LMS, 4P10, 5HVG, 5HVH, 5HVF
Identifiers
Aliases	CPB2, CPU, PCPB, TAFI, carboxypeptidase B2
External IDs	MGI: 1891837 HomoloGene: 55610 GeneCards: CPB2
Gene location (Human) Chr. Chromosome 13 (human) Band n/a Start 46,053,186 bp End 46,105,076 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band n/a Start 75,242,287 bp End 75,283,551 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • peptidase activity • hydrolase activity • zinc ion binding • carboxypeptidase activity • metallopeptidase activity • metallocarboxypeptidase activity Cellular component • cell • extracellular exosome • extracellular space • extracellular region Biological process • blood coagulation • negative regulation of hepatocyte proliferation • positive regulation of extracellular matrix constituent secretion • liver regeneration • cellular response to glucose stimulus • negative regulation of plasminogen activation • negative regulation of fibrinolysis • response to heat • hemostasis • response to drug • proteolysis • fibrinolysis • regulation of complement activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1361	56373
Ensembl	ENSG00000080618	ENSMUSG00000021999
UniProt	Q96IY4	Q9JHH6
RefSeq (mRNA)	NM_016413 NM_001278541 NM_001872	NM_019775
RefSeq (protein)	NP_001265470 NP_001863	NP_062749
Location (UCSC)	Chr 13: 46.05 – 46.11 Mb	Chr 13: 75.24 – 75.28 Mb
PubMed search

3D66, 3D67, 3D68, 3LMS, 4P10, 5HVG, 5HVH, 5HVF

1361

56373

ENSG00000080618

ENSMUSG00000021999

Q96IY4

Q9JHH6

NM_016413
NM_001278541
NM_001872

NM_019775

NP_001265470
NP_001863

NP_062749

Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2.

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