TAF15

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2MMY

Identifiers

Aliases

TAF15, Npl3, RBP56, TAF2N, TAFII68, TATA-box binding protein associated factor 15

External IDs

MGI: 1917689 HomoloGene: 131088 GeneCards: TAF15

Gene ontology
Molecular function	• DNA binding • zinc ion binding • protein binding • metal ion binding • nucleic acid binding • RNA binding
Cellular component	• cytoplasm • nucleolus • nucleus • nucleoplasm
Biological process	• positive regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8148


70439

Ensembl


n/a


ENSMUSG00000020680

UniProt


Q92804


n/a

RefSeq (mRNA)


NM_003487 NM_139215


NM_027427

RefSeq (protein)


NP_003478 NP_631961


n/a

Location (UCSC)

Chr 17: 35.71 – 35.86 Mb

Chr 11: 83.47 – 83.51 Mb

PubMed search

n/a

n/a

n/a

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.

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