Syndecan-1

SDC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GVC, 4GVD
Identifiers
Aliases	SDC1, CD138, SDC, SYND1, syndecan, syndecan 1
External IDs	OMIM: 186355 MGI: 1349162 HomoloGene: 2252 GeneCards: SDC1
Gene ontology Molecular function • protein C-terminus binding • glycoprotein binding • protein binding Cellular component • lysosomal lumen • extracellular exosome • extracellular region • integral component of membrane • Golgi lumen • integral component of plasma membrane • membrane • cell surface • plasma membrane • protein complex • external side of plasma membrane Biological process • glycosaminoglycan catabolic process • canonical Wnt signaling pathway • wound healing • response to calcium ion • odontogenesis • glycosaminoglycan biosynthetic process • ureteric bud development • response to cAMP • positive regulation of exosomal secretion • Sertoli cell development • striated muscle cell development • positive regulation of extracellular exosome assembly • retinoid metabolic process • response to glucocorticoid • response to toxic substance • response to organic substance • response to hydrogen peroxide • glycosaminoglycan metabolic process • inflammatory response • myoblast development • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6382	20969
Ensembl	ENSG00000115884	ENSMUSG00000020592
UniProt	P18827	P18828
RefSeq (mRNA)	NM_001006946 NM_002997	NM_011519
RefSeq (protein)	NP_001006947 NP_002988	NP_035649.1 NP_035649
Location (UCSC)	Chr 2: 20.2 – 20.23 Mb	Chr 12: 8.77 – 8.79 Mb
PubMed search

4GVC, 4GVD

6382

20969

ENSG00000115884

ENSMUSG00000020592

P18827

P18828

NM_001006946
NM_002997

NM_011519

NP_001006947
NP_002988

NP_035649.1
NP_035649

Syndecan 1 is a protein which in humans is encoded by the SDC1 gene.

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-1 is a sponge for growth factors, with binding largely via heparan sulfate chains.

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Wikipedia