Synaptophysin

SYP
Identifiers
Aliases	SYP, MRX96, MRXsynaptophysin
External IDs	OMIM: 313475 MGI: 98467 HomoloGene: 2391 GeneCards: SYP
Gene ontology Molecular function • transporter activity • SH2 domain binding • protein self-association • cholesterol binding • identical protein binding Cellular component • integral component of membrane • membrane • synaptic vesicle • synapse • excitatory synapse • synaptic vesicle membrane • presynaptic active zone • cell junction • terminal bouton • integral component of synaptic vesicle membrane • neuron projection • neuron projection terminus • presynaptic membrane • cytoplasmic vesicle • neuromuscular junction Biological process • cellular response to organic substance • regulation of long-term neuronal synaptic plasticity • endocytosis • regulation of opioid receptor signaling pathway • regulation of short-term neuronal synaptic plasticity • synaptic vesicle membrane organization • transport • regulation of neuronal synaptic plasticity • synaptic vesicle maturation • synaptic vesicle endocytosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6855	20977
Ensembl	ENSG00000102003	ENSMUSG00000031144
UniProt	P08247	Q62277
RefSeq (mRNA)	NM_003179	NM_009305
RefSeq (protein)	NP_003170	NP_033331.2 NP_033331
Location (UCSC)	Chr X: 49.19 – 49.2 Mb	Chr X: 7.64 – 7.65 Mb
PubMed search

6855

20977

ENSG00000102003

ENSMUSG00000031144

P08247

Q62277

NM_003179

NM_009305

NP_003170

NP_033331.2
NP_033331

Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene.

The gene is located on the short arm of X chromosome (Xp11.23-p11.22). It is 12,406 bases in length and lies on the minus strand. The encoded protein has 313 amino acids with a predicted molecular weight of 33.845 kDa.

The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses.

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