Syk

SYK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A81, 1CSY, 1CSZ, 1XBA, 1XBB, 1XBC, 3BUW, 3EMG, 3FQE, 3FQH, 3FQS, 3SRV, 3TUB, 3TUC, 3TUD, 3VF8, 3VF9, 4DFL, 4DFN, 4F4P, 4FL1, 4FL2, 4FL3, 4FYN, 4FYO, 4FZ6, 4FZ7, 4GFG, 4I0R, 4I0S, 4I0T, 4PUZ, 4PV0, 4PX6, 4RX7, 4RX8, 4RX9, 5CXH, 5CXZ, 5CY3, 4XG6, 4XG2, 4XG3, 4XG8, 4XG7, 4YJR, 4YJP, 5C27, 4RSS, 4XG4, 5C26, 4YJV, 4YJO, 4WNM, 4YJT, 4YJU, 4YJS, 4XG9, 5GHV
Identifiers
Aliases	SYK, p72-Syk, spleen tyrosine kinase, spleen associated tyrosine kinase
External IDs	OMIM: 600085 MGI: 99515 HomoloGene: 2390 GeneCards: SYK
Genetically Related Diseases
type 2 diabetes mellitus, multiple sclerosis, vascular dementia
Gene ontology Molecular function • kinase activity • ATP binding • protein kinase activity • signal transducer, downstream of receptor, with protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • protein serine/threonine kinase activity • transferase activity • integrin binding • protein binding • protein tyrosine kinase activity • protein kinase binding • nucleotide binding • phosphatase binding • Toll-like receptor binding Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • nucleus • early phagosome • B cell receptor complex • plasma membrane • T cell receptor complex • protein complex Biological process • leukocyte cell-cell adhesion • adaptive immune response • positive regulation of receptor internalization • neutrophil activation involved in immune response • platelet activation • Fc-epsilon receptor signaling pathway • protein phosphorylation • cell surface receptor signaling pathway • regulation of sequence-specific DNA binding transcription factor activity • serotonin secretion • angiogenesis • animal organ morphogenesis • positive regulation of cell adhesion mediated by integrin • cell proliferation • regulation of platelet aggregation • B cell receptor signaling pathway • positive regulation of calcium-mediated signaling • blood vessel morphogenesis • activation of JUN kinase activity • Fc-gamma receptor signaling pathway involved in phagocytosis • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cytokine secretion • regulation of tumor necrosis factor-mediated signaling pathway • serotonin secretion by platelet • cellular response to low-density lipoprotein particle stimulus • stimulatory C-type lectin receptor signaling pathway • lymph vessel development • neutrophil chemotaxis • macrophage activation involved in immune response • defense response to bacterium • positive regulation of alpha-beta T cell proliferation • regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • protein autophosphorylation • leukotriene biosynthetic process • positive regulation of interleukin-3 biosynthetic process • viral process • positive regulation of alpha-beta T cell differentiation • cellular response to molecule of fungal origin • regulation of neutrophil degranulation • phosphorylation • immune system process • positive regulation of B cell differentiation • beta selection • leukocyte activation involved in immune response • transcription factor import into nucleus • positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process • activation of MAPK activity • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • regulation of superoxide anion generation • enzyme linked receptor protein signaling pathway • intracellular signal transduction • receptor internalization • positive regulation of bone resorption • positive regulation of mast cell degranulation • regulation of arachidonic acid secretion • peptidyl-serine phosphorylation • peptidyl-tyrosine phosphorylation • regulation of phagocytosis • regulation of platelet activation • positive regulation of gamma-delta T cell differentiation • positive regulation of type I interferon production • inflammatory response • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6850	20963
Ensembl	ENSG00000165025	ENSMUSG00000021457
UniProt	P43405	P48025
RefSeq (mRNA)	NM_001135052 NM_001174167 NM_001174168 NM_003177	NM_001198977 NM_011518
RefSeq (protein)	NP_001128524 NP_001167638 NP_001167639 NP_003168	NP_001185906.1 NP_035648.2 NP_001185906 NP_035648
Location (UCSC)	Chr 9: 90.8 – 90.9 Mb	Chr 13: 52.58 – 52.65 Mb
PubMed search

1A81, 1CSY, 1CSZ, 1XBA, 1XBB, 1XBC, 3BUW, 3EMG, 3FQE, 3FQH, 3FQS, 3SRV, 3TUB, 3TUC, 3TUD, 3VF8, 3VF9, 4DFL, 4DFN, 4F4P, 4FL1, 4FL2, 4FL3, 4FYN, 4FYO, 4FZ6, 4FZ7, 4GFG, 4I0R, 4I0S, 4I0T, 4PUZ, 4PV0, 4PX6, 4RX7, 4RX8, 4RX9, 5CXH, 5CXZ, 5CY3, 4XG6, 4XG2, 4XG3, 4XG8, 4XG7, 4YJR, 4YJP, 5C27, 4RSS, 4XG4, 5C26, 4YJV, 4YJO, 4WNM, 4YJT, 4YJU, 4YJS, 4XG9, 5GHV

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