Surfactant protein C
| Surfactant protein C, N terminal propeptide | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Pulmonary surfactant-associated polypeptide SP-C Protein
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| Identifiers | |||||||||
| Symbol | SP_C-Propep | ||||||||
| Pfam | PF08999 | ||||||||
| InterPro | IPR001729 | ||||||||
| PROSITE | PDOC00298 | ||||||||
| OPM superfamily | 75 | ||||||||
| OPM protein | 1spf | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| surfactant, pulmonary-associated protein C | |
|---|---|
| Identifiers | |
| Symbol | SFTPC |
| Alt. symbols | SFTP2 |
| Entrez | 6440 |
| HUGO | 10802 |
| OMIM | 178620 |
| RefSeq | NM_003018 |
| UniProt | P11686 |
| Other data | |
| Locus | Chr. 8 p21 |
Surfactant proteins C are a family of related pulmonary surfactant proteins.
The propeptide of human protein from this family has an N-terminal alpha-helical segment whose suggested function was stabilization of the protein structure, since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide.
This article incorporates text from the public domain Pfam and InterPro IPR015091
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