Sulfadoxine

Sulfadoxine

Clinical data
AHFS/Drugs.com	International Drug Names
ATCvet code	QJ01EQ13 (WHO)
Identifiers
IUPAC name 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
CAS Number	2447-57-6 Y
PubChem CID	17134
DrugBank	DB01299 N
ChemSpider	16218 N
UNII	88463U4SM5
KEGG	D00580 Y
ChEMBL	CHEMBL1539 N
NIAID ChemDB	007816
ECHA InfoCard	100.017.732
Chemical and physical data
Formula	C12H14N4O4S
Molar mass	310.33 g/mol
3D model (Jmol)	Interactive image
SMILES COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N
NY (what is this?)

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.

It was previously used to prevent malaria but due to high levels of resistance, this use is no longer recommended routinely.

It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.