Substituted methylenedioxyphenethylamine

Substituted methylenedioxy- phenethylamines (MDxx) are a large chemical class of derivatives of the phenethylamines, which includes many psychoactive drugs that act as entactogens, psychedelics, and/or stimulants, as well as entheogens. These agents are used as research chemicals, designer drugs and as recreational substances.

When referring to MDMA and its counterparts, the term 'MDxx' is often used with the exception of MDPV.

The base compound of the MDxx class is 3,4-methylenedioxyphenethylamine (MDPEA), and the prototypical agent of this class is 3,4-methylenedioxy-N-methylamphetamine (MDMA; "ecstasy"). Other mentionables include 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA; "Eve"), N-methyl-1,3-benzodioxolylbutanamine (MBDB; "Eden"), and 3,4-methylenedioxy-N-methylcathinone (bk-MDMA; "Methylone").

The compounds most commonly regarded as comprising the family of MDxx derivatives include:

In addition, there are a number of other compounds that, while in the technical sense not phenethylamine derivatives, still have some structural and pharmacological similarities to the methylenedioxyphenethylamines. This makes them useful for comparison.

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