Stromal cell-derived factor-1

CXCL12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A15, 1QG7, 1SDF, 1VMC, 2J7Z, 2K01, 2K03, 2K04, 2K05, 2KEC, 2KED, 2KEE, 2KOL, 2NWG, 2SDF, 3GV3, 3HP3, 4LMQ, 4UAI, 2N55
Identifiers
Aliases	CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12
External IDs	MGI: 103556 HomoloGene: 128606 GeneCards: CXCL12
Gene location (Human) Chr. Chromosome 10 (human) Band 10q11.21 Start 44,370,165 bp End 44,386,493 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 54.81 cM|6 F1 Start 117,168,535 bp End 117,181,367 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • chemokine receptor binding • cytokine activity • chemokine activity • CXCR chemokine receptor binding • chemoattractant activity • growth factor activity • receptor binding Cellular component • plasma membrane • extracellular region • extracellular exosome • external side of plasma membrane • extracellular space • cytoplasm Biological process • negative regulation of leukocyte tethering or rolling • G-protein coupled receptor signaling pathway • regulation of calcium ion transport • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of cell migration • chemokine-mediated signaling pathway • adult locomotory behavior • response to mechanical stimulus • response to peptide hormone • positive regulation of monocyte chemotaxis • cellular calcium ion homeostasis • response to virus • neuron migration • response to heat • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of axon extension involved in axon guidance • blood circulation • telencephalon cell migration • axon guidance • chemotaxis • regulation of actin polymerization or depolymerization • positive regulation of calcium ion import • brain development • cell adhesion • positive regulation of dopamine secretion • animal organ regeneration • positive regulation of neuron differentiation • immune response • positive regulation of cell proliferation • cell chemotaxis • negative regulation of leukocyte apoptotic process • response to radiation • positive regulation of T cell migration • positive regulation of cell adhesion • signal transduction • positive chemotaxis • induction of positive chemotaxis • defense response • response to ultrasound • antimicrobial humoral immune response mediated by antimicrobial peptide • T cell chemotaxis • detection of temperature stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception of pain Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6387	20315
Ensembl	ENSG00000107562	ENSMUSG00000061353
UniProt	P48061	P40224
RefSeq (mRNA)	NM_199168 NM_000609 NM_001033886 NM_001178134 NM_001277990	NM_001012477 NM_013655 NM_021704
RefSeq (protein)	NP_000600 NP_001029058 NP_001171605 NP_001264919 NP_954637	NP_001012495 NP_038683 NP_068350
Location (UCSC)	Chr 10: 44.37 – 44.39 Mb	Chr 10: 117.17 – 117.18 Mb
PubMed search

1A15, 1QG7, 1SDF, 1VMC, 2J7Z, 2K01, 2K03, 2K04, 2K05, 2KEC, 2KED, 2KEE, 2KOL, 2NWG, 2SDF, 3GV3, 3HP3, 4LMQ, 4UAI, 2N55

6387

20315

ENSG00000107562

ENSMUSG00000061353

...
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