Coordinates: 55°52′41″N 4°34′26″W / 55.878°N 4.574°W
Strathgryffe or Gryffe Valley (both also spelled Gryfe) (Gaelic: Srath Ghriobhaidh) is a strath centred on the River Gryffe in the west central Lowlands of Scotland.
The river and its strath extend over the historic county of Renfrewshire. Strathgryfe, anciently a feudal lordship, is associated historically with the origins of the county and was anciently the name was used not only for the Strath of Gryffe itself, but for the whole of Renfrewshire. The River Gryffe passes through the council areas of Inverclyde and Renfrewshire, rising in Kilmacolm and joining the Black Cart Water between Houston and Inchinnan.
The lands of Strathgryffe were granted by King David I to Walter fitz Alan, first High Steward of Scotland, and founder of the Stewart family in Scotland in the 1130s.