Steroid sulfatase

STS
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1P49
Identifiers
Aliases	STS, ARSC, ARSC2, ARSC1, ASC, ES, SSDD, XLI, Steroid sulfatase (microsomal), isozyme S
External IDs	HomoloGene: 47918 GeneCards: STS
Gene ontology Molecular function • metal ion binding • catalytic activity • steryl-sulfatase activity • sulfuric ester hydrolase activity • hydrolase activity Cellular component • integral component of membrane • endosome • Golgi apparatus • endoplasmic reticulum lumen • membrane • endoplasmic reticulum membrane • plasma membrane • endoplasmic reticulum • lysosome • intracellular membrane-bounded organelle Biological process • steroid metabolic process • glycosphingolipid metabolic process • lipid metabolic process • post-translational protein modification • female pregnancy • steroid catabolic process • epidermis development • metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	412	n/a
Ensembl	ENSG00000101846	n/a
UniProt	P08842	n/a
RefSeq (mRNA)	NM_000351 NM_001320750 NM_001320751 NM_001320752 NM_001320753 NM_001320754	n/a
RefSeq (protein)	NP_000342 NP_001307679 NP_001307680 NP_001307681 NP_001307682 NP_001307683	n/a
Location (UCSC)	Chr X: 7.22 – 7.35 Mb	n/a
PubMed search		n/a

1P49

412

n/a

ENSG00000101846

n/a

P08842

n/a

NM_001320754

n/a

NP_001307683

n/a

Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.

The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to the free steroid. This includes DHEA sulfate, estrone sulfate, pregnenolone sulfate, and cholesterol sulfate, all to their unconjugated forms (DHEA, estrone, pregnenolone, and cholesterol, respectively). The encoded protein is found in the endoplasmic reticulum, where it is present as a homodimer.

A congenital deficiency in the enzyme is associated with X-linked ichthyosis, a scaly-skin disease affecting roughly 1 in every 2,000 to 6,000 males. The excessive skin scaling or hyperkeratosis is caused by a lack of breakdown and thus accumulation of cholesterol sulfate, a steroid that stabilizes cell membranes and adds cohesion, in the outer layers of the skin.

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