Steroid 11-beta-hydroxylase

CYP11B1
Identifiers
Aliases	CYP11B1, CPN1, CYP11B, FHI, P450C11, cytochrome P450 family 11 subfamily B member 1
External IDs	OMIM: 610613 MGI: 88584 HomoloGene: 128035 GeneCards: CYP11B1
EC number	1.14.15.4
Targeted by Drug
fadrozole, metyrapone, mitotane
Gene ontology Molecular function • iron ion binding • corticosterone 18-monooxygenase activity • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • steroid 11-beta-monooxygenase activity Cellular component • membrane • mitochondrial membrane • mitochondrion • mitochondrial inner membrane Biological process • glucose homeostasis • lipid metabolic process • secondary metabolite biosynthetic process • aldosterone biosynthetic process • cholesterol metabolic process • cortisol biosynthetic process • regulation of blood pressure • C21-steroid hormone biosynthetic process • cellular response to hormone stimulus • glucocorticoid biosynthetic process • cellular response to peptide hormone stimulus • immune response • sterol metabolic process • oxidation-reduction process • cellular response to potassium ion • steroid biosynthetic process • steroid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1584	13072
Ensembl	ENSG00000160882	ENSMUSG00000022589
UniProt	P15538	P15539
RefSeq (mRNA)	NM_000497 NM_001026213	NM_009991
RefSeq (protein)	NP_000488 NP_001021384	NP_034121.3
Location (UCSC)	Chr 8: 142.87 – 142.88 Mb	Chr 15: 74.85 – 74.86 Mb
PubMed search

steroid 11β-monooxygenase
Identifiers
EC number	1.14.15.4
CAS number	9029-66-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

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PMC	articles
PubMed	articles
NCBI	proteins

1584

13072

ENSG00000160882

ENSMUSG00000022589

P15538

P15539

NM_000497
NM_001026213

NM_009991

NP_000488
NP_001021384

NP_034121.3

Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata. Named officially the cytochrome P450 11B1, mitochondrial, it is a protein that in humans is encoded by the CYP11B1 gene.

This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of 11-deoxycortisol to cortisol in the adrenal cortex. Transcript variants encoding different isoforms have been noted for this gene.

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