Stat3

STAT3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
5AX3

Identifiers

Aliases

STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3

External IDs

OMIM: 102582 MGI: 103038 HomoloGene: 7960 GeneCards: STAT3

Genetically Related Diseases

Crohn's disease, multiple sclerosis

Gene ontology
Molecular function	• protein dimerization activity • CCR5 chemokine receptor binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein phosphatase binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • glucocorticoid receptor binding • protein binding • protein kinase binding • DNA binding • sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • signal transducer activity • RNA polymerase II repressing transcription factor binding • identical protein binding • chromatin DNA binding
Cellular component	• cytoplasm • mitochondrion • nucleus • nuclear chromatin • plasma membrane • nucleoplasm • RNA polymerase II transcription factor complex • mitochondrial inner membrane • cytosol
Biological process	• movement of cell or subcellular component • negative regulation of glycolytic process • protein import into nucleus • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • response to organic substance • positive regulation of gene silencing by miRNA • cellular response to cytokine stimulus • radial glial cell differentiation • stem cell population maintenance • cellular response to hormone stimulus • regulation of mitochondrial membrane permeability • growth hormone receptor signaling pathway • miRNA mediated inhibition of translation • eye photoreceptor cell differentiation • positive regulation of metalloendopeptidase activity • temperature homeostasis • cell proliferation • response to leptin • response to ethanol • positive regulation of Notch signaling pathway • negative regulation of cell proliferation • response to cytokine • regulation of transcription, DNA-templated • glucose homeostasis • cytokine-mediated signaling pathway • negative regulation of cell death • transcription, DNA-templated • positive regulation of growth factor dependent skeletal muscle satellite cell proliferation • positive regulation of transcription, DNA-templated • negative regulation of hydrogen peroxide biosynthetic process • energy homeostasis • viral process • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of neuron death • sexual reproduction • phosphorylation • leptin-mediated signaling pathway • cellular response to organic cyclic compound • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • regulation of feeding behavior • nervous system development • positive regulation of ATP biosynthetic process • interleukin-6-mediated signaling pathway • intracellular receptor signaling pathway • acute-phase response • negative regulation of neuron migration • JAK-STAT cascade • response to estradiol • response to organic cyclic compound • eating behavior • somatic stem cell population maintenance • regulation of multicellular organism growth • aging • response to peptide hormone • cellular response to leptin stimulus • regulation of cell cycle • astrocyte differentiation • response to drug • signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of tyrosine phosphorylation of Stat3 protein • JAK-STAT cascade involved in growth hormone signaling pathway • positive regulation of gene expression • negative regulation of stem cell differentiation • positive regulation of cell proliferation • mRNA transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6774


20848

Ensembl


ENSG00000168610


ENSMUSG00000004040

UniProt


P40763


P42227

RefSeq (mRNA)


NM_003150 NM_139276 NM_213662


NM_011486 NM_213659 NM_213660

RefSeq (protein)


NP_003141 NP_644805 NP_998827


NP_998824.1 NP_998825.1 NP_035616 NP_998824 NP_998825

Location (UCSC)

Chr 17: 42.31 – 42.39 Mb

Chr 11: 100.89 – 100.94 Mb

PubMed search

NM_003150
NM_139276
NM_213662

NM_011486
NM_213659
NM_213660

NP_003141
NP_644805
NP_998827

NP_998824.1
NP_998825.1
NP_035616
NP_998824
NP_998825

...
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