Src (gene)

SRC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4F, 1O4G, 1O4H, 1O4I, 1O4J, 1O4K, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 1O4R, 1SHD, 1Y57, 1YI6, 1YOJ, 1YOL, 1YOM, 2BDF, 2H8H, 3VRO, 3ZMP, 3ZMQ, 4F59, 4F5A, 4F5B, 4HXJ, 4K11, 4MXO, 4MXX, 4MXY, 4MXZ
Identifiers
Aliases	SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6
External IDs	MGI: 98397 HomoloGene: 21120 GeneCards: SRC
Targeted by Drug
bosutinib, dasatinib anhydrous, saracatinib, SU6656
Gene ontology Molecular function • ion channel binding • protein domain specific binding • protein complex binding • SH2 domain binding • kinase activity • protein C-terminus binding • receptor binding • estrogen receptor binding • ATP binding • protein kinase activity • insulin receptor binding • non-membrane spanning protein tyrosine kinase activity • kinase binding • heme binding • enzyme binding • transferase activity • ephrin receptor binding • scaffold protein binding • integrin binding • protein binding • protein tyrosine kinase activity • protein kinase binding • cell adhesion molecule binding • SH3/SH2 adaptor activity • protein kinase C binding • hormone receptor binding • nucleotide binding • growth factor receptor binding • phosphoprotein binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • ruffle membrane • mitochondrion • perinuclear region of cytoplasm • caveola • neuron projection • cytoskeleton • nucleus • lysosome • extracellular exosome • late endosome • plasma membrane • actin filament • postsynaptic density • mitochondrial inner membrane • cell-cell adherens junction Biological process • response to mineralocorticoid • negative regulation of telomere maintenance via telomerase • response to interleukin-1 • positive regulation of MAP kinase activity • positive regulation of canonical Wnt signaling pathway • negative regulation of telomerase activity • cellular response to progesterone stimulus • regulation of intracellular estrogen receptor signaling pathway • stress fiber assembly • positive regulation of protein serine/threonine kinase activity • platelet activation • positive regulation of smooth muscle cell migration • protein phosphorylation • regulation of vascular permeability • vascular endothelial growth factor receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • regulation of podosome assembly • cell cycle • substrate adhesion-dependent cell spreading • osteoclast development • cell proliferation • transforming growth factor beta receptor signaling pathway • cellular response to hypoxia • cellular response to transforming growth factor beta stimulus • negative regulation of protein homooligomerization • positive regulation of protein kinase B signaling • positive regulation of lamellipodium morphogenesis • epidermal growth factor receptor signaling pathway • branching involved in mammary gland duct morphogenesis • Fc-gamma receptor signaling pathway involved in phagocytosis • negative regulation of intrinsic apoptotic signaling pathway • positive regulation of cytokine secretion • negative regulation of extrinsic apoptotic signaling pathway • response to mechanical stimulus • response to virus • positive regulation of epithelial cell migration • signal complex assembly • stimulatory C-type lectin receptor signaling pathway • positive regulation of platelet-derived growth factor receptor signaling pathway • oogenesis • positive regulation of transcription, DNA-templated • regulation of epithelial cell migration • response to nutrient levels • positive regulation of DNA biosynthetic process • cellular response to insulin stimulus • protein autophosphorylation • viral process • negative regulation of focal adhesion assembly • response to acidic pH • single organismal cell-cell adhesion • response to fatty acid • regulation of cell projection assembly • phosphorylation • immune system process • negative regulation of mitochondrial depolarization • positive regulation of integrin activation • negative regulation of apoptotic process • cellular response to platelet-derived growth factor stimulus • positive regulation of podosome assembly • positive regulation of glucose metabolic process • transcytosis • cellular response to fluid shear stress • response to electrical stimulus • positive regulation of protein transport • uterus development • protein destabilization • regulation of cell-cell adhesion • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • positive regulation of insulin receptor signaling pathway • progesterone receptor signaling pathway • negative regulation of transcription, DNA-templated • adherens junction organization • negative regulation of anoikis • response to hydrogen peroxide • leukocyte migration • activation of protein kinase B activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • intracellular signal transduction • regulation of early endosome to late endosome transport • ephrin receptor signaling pathway • T cell costimulation • positive regulation of intracellular signal transduction • regulation of caveolin-mediated endocytosis • regulation of cell cycle • positive regulation of phosphatidylinositol 3-kinase activity • cellular response to reactive oxygen species • cellular response to peptide hormone stimulus • positive regulation of gene expression • cellular response to fatty acid • regulation of cell proliferation • angiotensin-activated signaling pathway involved in heart process • peptidyl-serine phosphorylation • positive regulation of protein autophosphorylation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of apoptotic process • peptidyl-tyrosine phosphorylation • forebrain development • regulation of protein binding • cellular response to lipopolysaccharide • regulation of bone resorption • cell migration • response to drug • signal transduction • positive regulation of cell adhesion • cell adhesion • positive regulation of protein processing • innate immune response • positive regulation of peptidyl-tyrosine phosphorylation • neurotrophin TRK receptor signaling pathway • positive regulation of small GTPase mediated signal transduction • bone resorption • central nervous system development • positive regulation of protein localization to nucleus • platelet-derived growth factor receptor signaling pathway • ERBB2 signaling pathway • intracellular estrogen receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6714	20779
Ensembl	ENSG00000197122	ENSMUSG00000027646
UniProt	P12931	P05480
RefSeq (mRNA)	NM_005417 NM_198291	NM_001025395 NM_009271
RefSeq (protein)	NP_005408 NP_938033	NP_001020566.1 NP_033297.2 NP_001020566 NP_033297
Location (UCSC)	Chr 20: 37.34 – 37.41 Mb	Chr 2: 157.42 – 157.47 Mb
PubMed search

1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4F, 1O4G, 1O4H, 1O4I, 1O4J, 1O4K, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 1O4R, 1SHD, 1Y57, 1YI6, 1YOJ, 1YOL, 1YOM, 2BDF, 2H8H, 3VRO, 3ZMP, 3ZMQ, 4F59, 4F5A, 4F5B, 4HXJ, 4K11, 4MXO, 4MXX, 4MXY, 4MXZ

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