The International spread of the printing press began with the invention of the printing press with movable type by Johannes Gutenberg in Mainz, Germany (circa 1439). Western printing technology was adopted in all world regions by the end of the 19th century, displacing the manuscript and block printing.
In the Western world, the operation of a press became synonymous with the enterprise of publishing and lent its name to a new branch of media, the press (see list of newspapers by date).
Gutenberg's first major print work was the 42-line Bible in Latin, printed probably between 1452 and 1454 in the German city of Mainz. After Gutenberg lost a lawsuit against his investor Johann Fust, Fust put Gutenberg's employee Peter Schöffer in charge of the print shop. Thereupon Gutenberg established a new one with the financial backing of another money lender. With Gutenberg's monopoly revoked, and the technology no longer secret, printing spread throughout Germany and beyond, diffused first by emigrating German printers, but soon also by foreign apprentices.
In rapid succession, printing presses were set up in Central and Western Europe. Major towns, in particular, functioned as centers of diffusion (Cologne 1466, Rome 1467, Venice 1469, Paris 1470, Kraków 1473, London 1477). In 1481, barely 30 years after the publication of the 42-line Bible, the small Netherlands already featured printing shops in 21 cities and towns, while Italy and Germany each had shops in about 40 towns at that time. According to one estimate, "by 1500, 1000 printing presses were in operation throughout Western Europe and had produced 8 million books." According to another, the output was in the order of twenty million volumes and rose in the sixteenth century tenfold to between 150 and 200 million copies. Germany and Italy were considered the two main centres of printing in terms of quantity and quality.