Dorsal root ganglion | |
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A dorsal root ganglion (DRG) from a chicken embryo (around stage of day 7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Axons growing out of the ganglion are visible.
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A spinal nerve with its ventral and dorsal roots. The dorsal root ganglion is the "spinal ganglion", following the dorsal root.
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Details | |
Precursor | neural crest |
Identifiers | |
Latin | ganglion sensorium nervi spinalis |
MeSH | A08.340.390.340 |
TA | A14.2.00.006 |
FMA | 5888 |
Anatomical terminology
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A dorsal root ganglion (or spinal ganglion) (also known as a posterior root ganglion), is a cluster of nerve cell bodies (a ganglion) in a posterior root of a spinal nerve. The dorsal root ganglia contain the cell bodies of sensory neurons (afferent).
The axons of dorsal root ganglion neurons are known as afferents. In the peripheral nervous system, afferents refer to the axons that relay sensory information into the central nervous system (i.e. the brain and the spinal cord). These neurons are of the pseudo-unipolar type, meaning they have an axon with two branches that act as a single axon, often referred to as a distal process and a proximal process.
Note: the neuron can consist of three parts:
In a neuron, the dendrite receives information from another neuron's axon at the synapse, and the axon sends information to the next neuron's dendrites, even though the dendrite may be covered with myelin.
Unlike the majority of neurons found in the central nervous system, an action potential in posterior root ganglion neuron may initiate in the distal process in the periphery, bypass the cell body, and continue to propagate along the proximal process until reaching the synaptic terminal in the posterior horn of spinal cord.
The distal section of the axon may either be a bare nerve ending or encapsulated by a structure that helps relay specific information to nerve. Two examples where the nerve ending of the distal process is encapsulated as such are, Meissner's corpuscles, which render the distal processes of mechanosensory neurons sensitive to stroking only, and Pacinian corpuscles, which make neurons more sensitive to vibration.