Sphingomyelin phosphodiesterase 1

SMPD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JG8
Identifiers
Aliases	SMPD1, ASM, ASMASE, NPD, Sphingomyelin phosphodiesterase 1
External IDs	MGI: 98325 HomoloGene: 457 GeneCards: SMPD1
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 6,390,431 bp End 6,394,998 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 E3|7 55.9 cM Start 105,554,360 bp End 105,558,389 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • sphingomyelin phosphodiesterase activity • hydrolase activity, acting on glycosyl bonds • protein binding • hydrolase activity • metal ion binding • zinc ion binding • acid sphingomyelin phosphodiesterase activity Cellular component • endosome • plasma membrane • lamellar body • lysosomal lumen • lysosome • extracellular exosome • extracellular region • extracellular space Biological process • termination of signal transduction • glycosphingolipid metabolic process • positive regulation of protein dephosphorylation • ceramide biosynthetic process • nervous system development • sphingomyelin catabolic process • negative regulation of MAP kinase activity • positive regulation of apoptotic process • metabolism • response to drug • signal transduction • sphingomyelin metabolic process • response to cocaine Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6609	20597
Ensembl	ENSG00000166311	ENSMUSG00000037049
UniProt	P17405	Q04519
RefSeq (mRNA)	NM_000543 NM_001007593 NM_001318087 NM_001318088	NM_011421
RefSeq (protein)	NP_000534 NP_001007594 NP_001305016 NP_001305017	NP_035551
Location (UCSC)	Chr 11: 6.39 – 6.39 Mb	Chr 11: 105.55 – 105.56 Mb
PubMed search

5JG8

6609

20597

ENSG00000166311

ENSMUSG00000037049

P17405

Q04519

NM_000543
NM_001007593
NM_001318087
NM_001318088

NM_011421

NP_000534
NP_001007594
NP_001305016
NP_001305017

NP_035551

Sphingomyelin phosphodiesterase 1 (SMPD1), also known as acid sphingomyelinase (ASM), is an enzyme that in humans is encoded by the SMPD1 gene.

Sphingomyelin phosphodiesterase 1 belongs to the sphingomyelin phosphodiesterase family.

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