Sp1 (biology)

SP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SP1, 1SP2, 1VA1, 1VA2, 1VA3
Identifiers
Aliases	SP1, entrez:6667, Sp1 transcription factor
External IDs	OMIM: 189906 MGI: 98372 HomoloGene: 8276 GeneCards: SP1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 53,380,176 bp End 53,416,446 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band n/a Start 102,406,143 bp End 102,436,404 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • HMG box domain binding • transcription factor binding • histone deacetylase binding • metal ion binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • bHLH transcription factor binding • protein C-terminus binding • protein binding • histone acetyltransferase binding • RNA polymerase II repressing transcription factor binding • nucleic acid binding • transcription regulatory region DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • DNA binding • double-stranded DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • core promoter sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • repressing transcription factor binding Cellular component • cytoplasm • nucleoplasm • protein-DNA complex • nucleus • nuclear chromatin • transcriptional repressor complex Biological process • positive regulation of hydrogen sulfide biosynthetic process • rhythmic process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • regulation of phenotypic switching by transcription from RNA polymerase II promoter • viral process • positive regulation by host of viral transcription • regulation of transcription, DNA-templated • transcription, DNA-templated • snRNA transcription from RNA polymerase II promoter • cellular response to insulin stimulus • positive regulation of transcription from RNA polymerase II promoter • regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6667	20683
Ensembl	ENSG00000185591	ENSMUSG00000001280
UniProt	P08047	O89090
RefSeq (mRNA)	NM_001251825 NM_003109 NM_138473	NM_013672
RefSeq (protein)	NP_001238754 NP_003100 NP_612482	NP_038700
Location (UCSC)	Chr 12: 53.38 – 53.42 Mb	Chr 12: 102.41 – 102.44 Mb
PubMed search

1SP1, 1SP2, 1VA1, 1VA2, 1VA3

6667

20683

ENSG00000185591

ENSMUSG00000001280

P08047

O89090

NM_001251825
NM_003109
NM_138473

NM_013672

NP_001238754
NP_003100
NP_612482

NP_038700

Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene.

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Wikipedia