Sox2

SOX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O4X, 2LE4
Identifiers
Aliases	SOX2, ANOP3, MCOPS3, SRY-box 2, Sox2
External IDs	MGI: 98364 HomoloGene: 68298 GeneCards: SOX2
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • miRNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription regulatory region sequence-specific DNA binding • protein binding • transcription regulatory region DNA binding Cellular component • cytoplasm • cytosol • transcription factor complex • nucleoplasm • nucleus Biological process • eye development • pituitary gland development • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • somatic stem cell population maintenance • endodermal cell fate specification • positive regulation of cell-cell adhesion • tissue regeneration • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription from RNA polymerase II promoter • regulation of cysteine-type endopeptidase activity involved in apoptotic process • adenohypophysis development • transcription, DNA-templated • neuronal stem cell population maintenance • positive regulation of transcription, DNA-templated • multicellular organism development • glial cell fate commitment • response to wounding • cell cycle arrest • osteoblast differentiation • positive regulation of cell differentiation • negative regulation of epithelial cell proliferation • regulation of gene expression • inner ear development • forebrain development • response to growth factor • negative regulation of canonical Wnt signaling pathway • positive regulation of MAPK cascade • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6657	20674
Ensembl	ENSG00000181449	ENSMUSG00000074637
UniProt	P48431	P48432
RefSeq (mRNA)	NM_003106	NM_011443
RefSeq (protein)	NP_003097	NP_035573.3 NP_035573
Location (UCSC)	Chr 3: 181.71 – 181.71 Mb	Chr 3: 34.65 – 34.65 Mb
PubMed search

1O4X, 2LE4

6657

20674

ENSG00000181449

ENSMUSG00000074637

P48431

P48432

NM_003106

NM_011443

NP_003097

NP_035573.3
NP_035573

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.

Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.

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Wikipedia