South Carolina Highway 49
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 78.7 mi (126.7 km) | |||
| Existed: | 1937 – present | |||
| Major junctions | ||||
| South end: |
 US 221 in Watts Mills
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 I-385 near Watts Millsl I-26 near Cross Anchor US 321 in York
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| North end: |
 NC 49 in Lake Wylie
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| Location | ||||
| Counties: | Laurens, Spartanburg, Union, Chester, York | |||
| Highway system | ||||
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South Carolina Highway 49 is a primary state highway in the U.S. state of South Carolina. It traverses north–south from Watts Mills to the North Carolina state line, in Lake Wylie.
SC 49 is part of a three-state highway 49, that totals 325 miles (523 km), from Watts Mills, South Carolina to Crewe, Virginia.
Established in 1937 as a renumbering of SC 163; it ran from U.S. Route 321, in York, to the North Carolina state line, in Lake Wylie. In 1956, SC 49 was extended southwest to its current southern terminus at US 221, in Watts Mills; replacing SC 91 from York to Monarch, SC 92 from Monarch to Cross Anchor, and SC 30 from Cross Anchor to Watts Mills.
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