"Soul Sacrifice" is an instrumental written and recorded by the American rock group Santana. Identified as one of the highlights of the 1969 festival and , "Soul Sacrifice" features extended guitar passages by Carlos Santana and a percussion section with a solo by drummer Michael Shrieve. It is included as the final track on their 1969 debut album, Santana, and on several live and compilation albums. The studio and Woodstock versions as well as an alternate take are included on the 2004 25th anniversary of Santana.

"Soul Sacrifice" was one of Santana's earliest compositions. Carlos Santana recalled the group wrote it when bassist David Brown joined. It has been described as "a perfect example of the amalgam of old-world guaguanco rhythms and strictly American licks" and includes "interplay between Santana and [Gregg] Rolie ... hammered home by [Mike] Carabello's and [Jose 'Chepito'] Area's congas and the sinuous drums and bass of [Mike] Shrieve and Brown".

Before its release on their album, Santana, then a largely unknown band, performed "Soul Sacrifice" as their closing number at Woodstock. "They were the only act to play without a record; it was unparalleled. Santana went from Woodstock to being in global demand almost overnight". In several interviews, Santana recalled experiencing the effects of psychedelics during the performance, but got it together for the finale."By the time we got to 'Soul Sacrifice', I had come back from a pretty intense journey. Ultimately, I felt we had plugged in to a whole lot of hearts at Woodstock".

The reached number one in the Billboard Top LPs album chart; helped by the publicity generated by their Woodstock performance of "Soul Sacrifice", Santana's debut album reached number four. Several musical artists have recorded renditions, including Mother Earth, Os Paralamas do Sucesso, and Transatlantic. The song was featured in the David Fincher film Zodiac.

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