Somatostatin receptor 4

SSTR4

Identifiers

SSTR4, SS-4-R, SS4-R, SS4R, Somatostatin receptor 4

External IDs

MGI: 105372 HomoloGene: 20286 GeneCards: SSTR4

Gene ontology
Molecular function	• neuropeptide binding • G-protein coupled receptor activity • signal transducer activity • somatostatin receptor activity
Cellular component	• cytoplasm • integral component of membrane • neuron projection • plasma membrane • integral component of plasma membrane • membrane
Biological process	• G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • forebrain development • cellular response to glucocorticoid stimulus • negative regulation of cAMP metabolic process • cell migration • arachidonic acid metabolic process • positive regulation of MAPK cascade • negative regulation of cell proliferation • signal transduction • somatostatin signaling pathway • chemical synaptic transmission
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6754


20608

Ensembl


ENSG00000132671


ENSMUSG00000037014

UniProt


P31391


P49660

RefSeq (mRNA)


NM_001052


NM_009219

RefSeq (protein)


NP_001043


NP_033245.2 NP_033245

Location (UCSC)

Chr 20: 23.04 – 23.04 Mb

Chr 2: 148.4 – 148.4 Mb

PubMed search

NP_033245.2
NP_033245

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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