Somatostatin receptor 3

SSTR3
Identifiers
Aliases	SSTR3, SS-3-R, SS3-R, SS3R, SSR-28, Somatostatin receptor 3
External IDs	MGI: 98329 HomoloGene: 20285 GeneCards: SSTR3
Gene location (Human) Chr. Chromosome 22 (human) Band No data available Start 37,204,238 bp End 37,212,322 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band No data available Start 78,537,015 bp End 78,544,345 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • neuropeptide binding • signal transducer activity • protein binding • somatostatin receptor activity • receptor binding • G-protein coupled receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • integral component of plasma membrane • cilium • neuron projection • plasma membrane • ciliary membrane • non-motile cilium Biological process • G-protein coupled receptor signaling pathway • cell-cell signaling • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular response to estradiol stimulus • cerebellum development • cellular response to glucocorticoid stimulus • spermatogenesis • response to starvation • hormone-mediated apoptotic signaling pathway • forebrain development • signal transduction • negative regulation of cell proliferation • chemical synaptic transmission • somatostatin signaling pathway • neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6753	20607
Ensembl	ENSG00000278195	ENSMUSG00000044933
UniProt	P32745	P30935
RefSeq (mRNA)	NM_001051 NM_001278687	NM_009218
RefSeq (protein)	NP_001042 NP_001265616	NP_033244
Location (UCSC)	Chr 22: 37.2 – 37.21 Mb	Chr 22: 78.54 – 78.54 Mb
PubMed search

6753

20607

ENSG00000278195

ENSMUSG00000044933

P32745

P30935

NM_001051
NM_001278687

NM_009218

NP_001042
NP_001265616

NP_033244

Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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