Somatostatin receptor 2

SSTR2
Identifiers
Aliases	SSTR2, Somatostatin receptor 2
External IDs	MGI: 98328 HomoloGene: 37427 GeneCards: SSTR2
Gene ontology Molecular function • protein binding • signal transducer activity • G-protein coupled receptor activity • neuropeptide binding • PDZ domain binding • somatostatin receptor activity Cellular component • integral component of plasma membrane • cytoplasm • integral component of membrane • membrane • neuron projection • plasma membrane • cytosol Biological process • response to nutrient • cerebellum development • regulation of muscle contraction • neuropeptide signaling pathway • digestion • peristalsis • cellular response to glucocorticoid stimulus • G-protein coupled receptor signaling pathway • response to starvation • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • negative regulation of cell proliferation • cell-cell signaling • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • spermatogenesis • cellular response to estradiol stimulus • signal transduction • forebrain development • somatostatin signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6752	20606
Ensembl	ENSG00000180616	ENSMUSG00000047904
UniProt	P30874	P30875
RefSeq (mRNA)	NM_001050	NM_001042606 NM_009217
RefSeq (protein)	NP_001041	NP_001036071.1 NP_033243.2 NP_001036071 NP_033243
Location (UCSC)	Chr 17: 73.17 – 73.18 Mb	Chr 11: 113.62 – 113.63 Mb
PubMed search

6752

20606

ENSG00000180616

ENSMUSG00000047904

P30874

P30875

NM_001050

NM_001042606
NM_009217

NP_001041

NP_001036071.1
NP_033243.2
NP_001036071
NP_033243

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.

Somatostatin receptor 2 has been shown to interact with SHANK2.

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Wikipedia