Somatostatin

SST
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MI1
Identifiers
Aliases	SST, SMST, somatostatin, Somatostatin
External IDs	OMIM: 182450 MGI: 98326 HomoloGene: 819 GeneCards: SST
Gene ontology Molecular function • hormone activity Cellular component • extracellular region • neuronal cell body • extracellular space Biological process • negative regulation of cell proliferation • hormone-mediated apoptotic signaling pathway • hyperosmotic response • chemical synaptic transmission • regulation of cell migration • response to heat • response to nutrient • response to acidic pH • response to drug • response to steroid hormone • G-protein coupled receptor signaling pathway • response to amino acid • cell-cell signaling • response to organonitrogen compound • digestion • cell surface receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6750	20604
Ensembl	ENSG00000157005	ENSMUSG00000004366
UniProt	P61278	P60041
RefSeq (mRNA)	NM_001048	NM_009215
RefSeq (protein)	NP_001039	NP_033241.1 NP_033241
Location (UCSC)	Chr 3: 187.67 – 187.67 Mb	Chr 16: 23.89 – 23.89 Mb
PubMed search

2MI1

6750

20604

ENSG00000157005

ENSMUSG00000004366

P61278

P60041

NM_001048

NM_009215

NP_001039

NP_033241.1
NP_033241

Somatostatin, also known as growth hormone–inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion.

Somatostatin has two active forms produced by alternative cleavage of a single preproprotein: one of 14 amino acids (shown in infobox to right), the other of 28 amino acids which is the short form with another 14 amino acids at one end.

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