Soluble epoxide hydrolase

EPHX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S8O, 1VJ5, 1ZD2, 1ZD3, 1ZD4, 1ZD5, 3ANS, 3ANT, 3I1Y, 3I28, 3KOO, 3OTQ, 3PDC, 3WK4, 3WK5, 3WK6, 3WK7, 3WK8, 3WK9, 3WKA, 3WKB, 3WKC, 3WKD, 3WKE, 4C4X, 4C4Y, 4C4Z, 4HAI, 4J03, 4JNC, 4OCZ, 4OD0, 4X6X, 4X6Y, 4Y2J, 4Y2P, 4Y2Q, 4Y2R, 4Y2S, 4Y2T, 4Y2U, 4Y2V, 4Y2X, 4Y2Y, 5AHX, 5AI0, 5AI4, 5AI5, 5AI6, 5AI8, 5AI9, 5AIA, 5AIB, 5AIC, 5AK3, 5AK4, 5AK5, 5AK6, 5AKE, 5AKG, 5AKH, 5AKI, 5AKJ, 5AKK, 5AKL, 5AKX, 5AKY, 5AKZ, 5ALD, 5ALE, 5ALF, 5ALG, 5ALH, 5ALI, 5ALJ, 5ALK, 5ALL, 5ALM, 5ALN, 5ALO, 5ALP, 5ALQ, 5ALR, 5ALS, 5ALT, 5ALU, 5ALV, 5ALW, 5ALX, 5ALY, 5ALZ, 5AM0, 5AM1, 5AM2, 5AM3, 5AM4, 5AM5, 5FP0
Identifiers
Aliases	EPHX2, CEH, SEH, Epoxide hydrolase 2
External IDs	MGI: 99500 HomoloGene: 37558 GeneCards: EPHX2
Gene ontology Molecular function • 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity • phosphatase activity • metal ion binding • catalytic activity • lipid phosphatase activity • receptor binding • hydrolase activity • magnesium ion binding • toxic substance binding • protein homodimerization activity • epoxide hydrolase activity Cellular component • extracellular exosome • peroxisome • cytosol • cytoplasm Biological process • phospholipid dephosphorylation • lipid metabolic process • positive regulation of vasodilation • epoxygenase P450 pathway • cellular calcium ion homeostasis • reactive oxygen species metabolic process • regulation of blood pressure • regulation of cholesterol metabolic process • stilbene catabolic process • drug metabolic process • xenobiotic metabolic process • metabolic process • aromatic compound catabolic process • inflammatory response • dephosphorylation • positive regulation of gene expression • response to toxic substance • cholesterol homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2053	13850
Ensembl	ENSG00000120915	ENSMUSG00000022040
UniProt	P34913	P34914
RefSeq (mRNA)	NM_001979 NM_001256482 NM_001256483 NM_001256484	NM_001271402 NM_001271403 NM_001271421 NM_007940
RefSeq (protein)	NP_001243411 NP_001243412 NP_001243413 NP_001970	NP_001258332.1 NP_031966.2
Location (UCSC)	Chr 8: 27.49 – 27.55 Mb	Chr 14: 66.08 – 66.12 Mb
PubMed search

1S8O, 1VJ5, 1ZD2, 1ZD3, 1ZD4, 1ZD5, 3ANS, 3ANT, 3I1Y, 3I28, 3KOO, 3OTQ, 3PDC, 3WK4, 3WK5, 3WK6, 3WK7, 3WK8, 3WK9, 3WKA, 3WKB, 3WKC, 3WKD, 3WKE, 4C4X, 4C4Y, 4C4Z, 4HAI, 4J03, 4JNC, 4OCZ, 4OD0, 4X6X, 4X6Y, 4Y2J, 4Y2P, 4Y2Q, 4Y2R, 4Y2S, 4Y2T, 4Y2U, 4Y2V, 4Y2X, 4Y2Y, 5AHX, 5AI0, 5AI4, 5AI5, 5AI6, 5AI8, 5AI9, 5AIA, 5AIB, 5AIC, 5AK3, 5AK4, 5AK5, 5AK6, 5AKE, 5AKG, 5AKH, 5AKI, 5AKJ, 5AKK, 5AKL, 5AKX, 5AKY, 5AKZ, 5ALD, 5ALE, 5ALF, 5ALG, 5ALH, 5ALI, 5ALJ, 5ALK, 5ALL, 5ALM, 5ALN, 5ALO, 5ALP, 5ALQ, 5ALR, 5ALS, 5ALT, 5ALU, 5ALV, 5ALW, 5ALX, 5ALY, 5ALZ, 5AM0, 5AM1, 5AM2, 5AM3, 5AM4, 5AM5, 5FP0

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