Sol Spiegelman

Sol Spiegelman
Sol Spiegelman
Born	(1914-12-14)December 14, 1914 Brooklyn, New York, U.S.
Died	January 20, 1983(1983-01-20) (aged 68) New York, New York, U.S.
Nationality	American
Fields	molecular biologist
Institutions	University of Illinois at Urbana-Champaign, Columbia University
Alma mater	City College of New York, Washington University in St. Louis
Known for	DNA structure, Cancer

Sol Spiegelman (December 14, 1914 – January 20, 1983) was an American molecular biologist. He developed the technique of nucleic acid hybridization, which helped to lay the groundwork for advances in recombinant DNA technology.

Spiegelman was born and educated in New York City, and earned a bachelor's degree in mathematics from the City College of New York in 1939. He began his graduate studies at Columbia University in 1940, looking into cellular physiology. He completed his graduate studies at Washington University in St. Louis (1942–44) where he also lectured in physics and applied mathematics, receiving his doctorate there in 1944. After a year as a U.S. Public Health Service Fellow at the University of Minnesota, he joined the faculty of the University of Illinois and later became a professor of microbiology where he stayed for 20 years.

In 1962, he improved a technique that allowed the detection of specific RNA and DNA molecules in cells. Called nucleic acid hybridization originally developed by Rich and Davies in 1956, it was the combination of viral DNA and viral RNA which helped to lay the groundwork for advances in recombinant DNA technology.

In 1969 he became a professor of human genetics and development at the Columbia University College of Physicians and Surgeons as well as director of the Institute of Cancer Research in 1969. In 1975, he was named University Professor.

He investigated how cells form enzymes, DNA and RNA structures, virology and the molecular basis of cancer. He is credited with an experiment with self reproducing RNA structures called Spiegelman's Monster.

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