Sodium salicylate

Sodium salicylate
Names

IUPAC name Sodium salicylate
Other names Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Sodium 2-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
Identifiers
CAS Number	54-21-7^Y
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL447868^Y
ChemSpider	5689^Y
DrugBank	DB01398^Y
ECHA InfoCard	100.000.181
EC Number	200-198-0
KEGG	D00566^N
PubChem	16760658
RTECS number	VO5075000
UNII	WIQ1H85SYP^Y
InChI InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1^Y Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M^Y InChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 Key: ABBQHOQBGMUPJH-REWHXWOFAO
SMILES [Na+].O=C([O-])c1ccccc1O
Properties
Chemical formula	C₇H₅NaO₃
Molar mass	160.10 g·mol⁻¹
Appearance	white crystals
Melting point	200 °C (392 °F; 473 K)
Solubility in water	25.08 g/100 mL (-1.5 °C) 107.9 g/100 mL (15 °C) 124.6 g/100 mL (25 °C) 141.8 g/100 mL (78.5 °C) 179 g/100 g (114 °C)
Solubility	soluble in glycerol, 1,4-Dioxane, alcohol
Solubility in methanol	26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C)
Pharmacology
ATC code	N02BA04 (WHO)
Hazards
Main hazards	Harmful
GHS pictograms
GHS signal word	Warning
GHS hazard statements	H314, H331, H400
GHS precautionary statements	P210, P261, P273, P280, P305+351+338, P310
EU classification (DSD)	Xn
R-phrases	R22, R36/37/38
S-phrases	S24/25, S26, S36/37/39
Eye hazard	Irritant
NFPA 704	1 1 0
Autoignition temperature	250 °C (482 °F; 523 K)
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	930 mg/kg (rats, oral)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N (what is ^YN ?)
Infobox references

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.

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