Sodium 17β-dihydroequilenin sulfate

17β-Dihydroequilenin

Clinical data
Routes of administration	Oral
Identifiers
IUPAC name (13S,14S,17S)-13-Methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol
CAS Number	1423-97-8
PubChem CID	3032407
ChemSpider	2297390
ChEMBL	CHEMBL123405
Chemical and physical data
Formula	C18H20O2
Molar mass	268.3502 g/mol
3D model (Jmol)	Interactive image
SMILES C[C@]12CCC3=C([C@@H]1CC[C@@H]2O)C=CC4=C3C=CC(=C4)O
InChI InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h2-5,10,16-17,19-20H,6-9H2,1H3/t16-,17-,18-/m0/s1 Key:RYWZPRVUQHMJFF-BZSNNMDCSA-N

17β-Dihydroequilenin, or β-dihydroequilenin, also known as 6,8-didehydro-17β-estradiol, as well as estra-1,3,5(10),6,8-pentaen-3,17β-diol, is a naturally occurring steroidal estrogen found in horses that is closely related to equilin, equilenin, and estradiol, and, as the 3-sulfate ester sodium salt, is a minor constituent (0.5%) of conjugated equine estrogens (Premarin). 17β-Dihydroequilenin has unexpectedly shown a selective estrogen receptor modulator-like profile of estrogenic activity in studies with monkeys, in which beneficial effects on bone and the cardiovascular system were noted but proliferative responses in breast or endometrium were not observed.