Premarin
| Combination of | |
|---|---|
| Sodium estrone sulfate | Estrogen |
| Sodium equilin sulfate | Estrogen |
| Sodium 17α-dihydroequilin sulfate | Estrogen |
| Clinical data | |
| Trade names | Premarin |
| AHFS/Drugs.com | Consumer Drug Information |
| Pregnancy category |
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| Routes of administration |
Oral, topical, IV |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Protein binding | >90% |
| Biological half-life | ~12 hours |
| Excretion | Renal |
| Identifiers | |
| Synonyms | Conjugated equine estrogens |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ECHA InfoCard | 100.006.475 |
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Premarin is the brand name for an estrogen medication that consists of conjugated estrogens isolated from the urine of pregnant mares (pregnant mares' urine). It is manufactured by Wyeth (now a part of Pfizer), and was first marketed in 1941 and 1942 in Canada and the United States, respectively, for the treatment of menopausal symptoms.
Premarin is available in oral (0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, or 2.5 mg pills),intravenous, and vaginal (cream) forms.
Premarin is a form of hormone replacement therapy (HRT). It is used most commonly in postmenopausal women who have had a hysterectomy to treat hot flashes, and burning, itching, and dryness of the vagina and surrounding areas. It can also be used in conjunction with a progestogen in women who have not had a hysterectomy. For women already taking the medication, it can be used to treat osteoporosis, although it is not recommended solely for this use. Some lesser known uses are the treatment of breast cancer in both men and women and the treatment of prostate cancer in men.
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