Sodium-iodide symporter

SLC5A5

Identifiers

SLC5A5, NIS, TDH1, solute carrier family 5 member 5

External IDs

MGI: 2149330 HomoloGene: 37311 GeneCards: SLC5A5

Gene ontology
Molecular function	• transporter activity • symporter activity • iodide transmembrane transporter activity • sodium:iodide symporter activity
Cellular component	• integral component of membrane • extracellular vesicle • membrane • extracellular exosome • nucleus • plasma membrane
Biological process	• sodium ion transmembrane transport • sodium ion transport • ion transport • anion transmembrane transport • cellular response to gonadotropin stimulus • cellular response to cAMP • transmembrane transport • thyroid hormone generation • iodide transport • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6528


114479

Ensembl


ENSG00000105641


ENSMUSG00000000792

UniProt


Q92911


Q99PN0

RefSeq (mRNA)


NM_000453


NM_053248

RefSeq (protein)


NP_000444


NP_444478

Location (UCSC)

Chr 19: 17.87 – 17.9 Mb

Chr 8: 70.88 – 70.89 Mb

PubMed search

A sodium/iodide symporter (NIS), also known as a sodium/iodide cotransporter or solute carrier family 5, member 5 (SLC5A5) is a protein that in humans is encoded by the SLC5A5 gene. It is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium cations (Na⁺) for each iodide anion (I⁻) into the cell. NIS mediated uptake of iodide into follicular cells of the thyroid gland is the first step in the synthesis of thyroid hormone.

Iodine uptake mediated by thyroid follicular cells from the blood plasma is the first step for the synthesis of thyroid hormones. This ingested iodine is bound to serum proteins, especially to albumins. The rest of the iodine which remains unlinked and free in bloodstream, is removed from the body through urine (the kidney is essential in the removal of iodine from extracellular space).

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Wikipedia