Smyth Channel (Spanish: Canal Smyth) is a principal Patagonia channel. Its south arm is the southward continuation of the Sarmiento Channel and is located in Magallanes y Antártica Chilena Region. The Kawésqar people lived along its coast for thousands of years.
Its north entrance is in the Nelson Strait at 51°36′10″S 74°48′12″W / 51.60278°S 74.80333°W, between Charlton Cape and the western extreme of the Lobos Islands; and its southern terminus is at 52°46′05″S 73°50′10″W / 52.76806°S 73.83611°W, between Phillip Cape at the southern extreme of Manuel Rodriguez Island and Merino Peninsula on the mainland, where it opens into the Strait of Magellan.