Siparuni River

The Siparuni River is a river in the Potaro-Siparuni Region of Guyana. It is a tributary of the Essequibo River. Tributaries of the Siparuni River include the Takutu River (Siparuni River), Burro-Burro River, Tipuru River and Levai Creek.

Archaic petroglyphs have been recorded in a number of locations on the Siparuni River, including Big "S" Falls.