Simeone Tagliavia d'Aragonia (1550–1604) was a Sicilian cardinal and bishop.
Simeone Tagliavia d'Aragonia was born in Castelvetrano, a family fief near Mazara del Vallo, Kingdom of Sicily on May 20, 1550, the son of Carlo d'Aragona Tagliavia, Viceroy of Sicily, and his wife Margherita Ventimiglia. He was the grand-nephew of Cardinal Pietro Tagliavia d'Aragonia.
At age 17, he was sent to Spain, where he studied at the University of Alcalá.
Pope Gregory XIII made him a cardinal deacon in the consistory of December 12, 1583. He did not participate in the papal conclave of 1585 that elected Pope Sixtus V. He received the red hat and the deaconry of Santa Maria degli Angeli e dei Martiri on May 20, 1585. That month, he was also appointed vice-protector of Spain.
He participated in the first papal conclave of 1590 that elected Pope Urban VII; in the second papal conclave of 1590 that elected Pope Gregory XIV; in the papal conclave of 1591 that elected Pope Innocent IX; and in the papal conclave of 1592 that elected Pope Clement VIII.