Sikhio (Thai: สีคิ้ว) is the central town of Sikhio district, Nakhon Ratchasima Province, north-eastern Thailand. It covers parts of the subdistricts Sikhio and Mittraphab, a total area of 11.63 km². As of 2007 it had a population of 18,663. The town is subdivided into 19 boroughs (chumchon).
Sikhio was established as a sanitary district (sukhaphiban) in 1956. In 1966 the area of the district was enlarged. Like all sanitary districts, it was upgraded to a subdistrict municipality (thesaban tambon) in 1999. Effective 31 January 2008 it was upgraded to a town (thesaban mueang).
Sikhio is on the north-eastern railway connecting Bangkok with Nakhon Ratchasima. Mittraphap Road passes south of the town.
Coordinates: 14°54′N 101°43′E / 14.900°N 101.717°E